Organic spectroscopy, the application of spectroscopic methods to determination of the structure of the molecules organic chemists are interested in, came of age during the Golden Sixties. The twin engines which lifted it to prominence were mass spectrometry (ms), which had been developed extensively in the nineteen-fifties when engineers analyzed the hydrocarbons present in oil; and nuclear magnetic resonance (nmr), which had been discovered in the immediate aftermath of World War II.
Organic spectroscopy arose out of a bleak, almost desertic landscape. In the early nineteen-fifties, available instrumental techniques were indirect only (dipolemetry, ultraviolet electronic spectra interpreted with the Woodward rules, infrared spectroscopy), limited to rather small or highly symmetrical molecules in the gas phase (electron diffraction, microwave spectrometry), or yet excruciatingly labor- and time-intensive (X-ray diffraction).
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